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Board-Certified Psychiatrist (ABPN)|U.S. + Israel Licensed|Telepsychiatry since 2013|Psychiatrist present during every IM session|Prescription treatment · Ages 18+ · Medical evaluation required

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Depression

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Understanding Treatment-Resistant Depression: When Traditional Therapies Aren't Enough

Learn about treatment-resistant depression, its causes, and how innovative treatments like KAP are providing new hope for patients who haven't found relief with conventional methods.

Dr. (Andrew) Dror Rosenbach

Published 11/16/2025

Updated 7/8/2026

8 min read

👁️ 24 views

Key Takeaways

Learn about treatment-resistant depression, its causes, and how innovative treatments like KAP are providing new hope for patients who haven't found relief with conventional methods.

•Ketamine is not a stand-alone cure.
•Secure intake, clinician review, and psychiatric evaluation are required before treatment.
•Preparation and integration shape the treatment.
•Not everyone is a candidate.
•The first step is a free KAP orientation conversation.

Considering ketamine therapy in Tel Aviv? Start with a free 15–20 minute KAP orientation conversation.

📞 Book Free KAP Orientation

Note: This article is for educational purposes only and does not constitute medical advice or a treatment recommendation. All KAP treatment requires formal psychiatric evaluation. If you are in crisis, call emergency services (Israel: 101) or ERAN: 1201.

What is Treatment-Resistant Depression?

Treatment-resistant depression (TRD) affects approximately 30% of people with major depressive disorder. It's diagnosed when a patient hasn't responded adequately to at least two different antidepressant medications tried at adequate doses and durations.

Understanding the Causes

Several factors can contribute to treatment resistance including genetic variations, underlying medical conditions, medication interactions, and the complexity of each individual's brain chemistry.

New Hope with Ketamine

Ketamine-Assisted Psychotherapy represents a breakthrough for TRD patients. Unlike traditional antidepressants that work on serotonin, ketamine targets glutamate receptors, offering rapid relief often within hours or days.

What to Expect

KAP treatment typically involves 6 sessions over 2-3 weeks, followed by maintenance sessions as needed. Many patients report significant improvement in mood, motivation, and overall quality of life.

Dr. (Andrew) Dror Rosenbach, MD

U.S. Board-Certified Psychiatrist · Israel-Licensed · Tel Aviv

Dr. Rosenbach is a board-certified psychiatrist specializing in Ketamine-Assisted Psychotherapy (KAP), treatment-resistant depression, and trauma. He offers in-home IM KAP sessions in Tel Aviv with structured preparation and integration. Learn more about Dr. Rosenbach →

Topics:

treatment-resistant depression

TRD

ketamine therapy

depression treatment

KAP Israel

psychiatrist Tel Aviv

Learn More

→ Ketamine Therapy in Tel Aviv → How KAP Works → Pricing & Services → Frequently Asked Questions → About Dr. Rosenbach → Book Free 15–20 Min KAP Orientation

Next Step

Not sure whether this is right for you?

Start with a free 15–20 minute orientation conversation. It's informational, not a psychiatric evaluation or risk assessment. Secure intake and clinician review come before any formal evaluation.

📞 Book Free KAP Orientation

The orientation does not determine treatment. A formal evaluation is offered only after secure-intake review.

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Feb 27, 2026

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